Finastéride/Proscar - Dosage

[kurt]

Bonjour,

Est-on obligé de prendre la dose de 1 Mg de finastéride/ jour ou peut-on descendre à 0.5 Mg voir 0.2 Mg.
Certains articles semblent suggérer que les dosages 0.5 et 0.2 ont presque les même effet que le 1 mg .

Un professionnel pour m'éclairer ?

Bien à vous,
Kurt.

[dermatologue]

La dose de 1 mg a été testé après des essais de doses ( l'article date de 1999), le voici - 0, 2 est efficace mais moins efficace que 1 mg alors que 5 mg n'est pas plus efficace que 1mg.

[URL="http://www.ncbi.nlm.nih.gov/pubmed/10495375#"]J Am Acad Dermatol.[/URL] 1999 Oct;41(4):555-63.
Clinical dose ranging studies with finasteride, a type 2 5alpha-reductase inhibitor, in men with male pattern hair loss.

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Source

Northwest Cutaneous Research Specialists, Portland, Oregan, USA.

Abstract

BACKGROUND:

Androgenetic alopecia is a common condition of adult men. Finasteride, a type 2 5alpha-reductase inhibitor, decreases the formation of dihydrotestosterone from testosterone.
OBJECTIVE:

Two separate clinical studies were conducted to establish the optimal dose of finasteride in men with this condition.
METHODS:

Men from 18 to 36 years of age with moderate vertex male pattern hair loss received finasteride 5, 1, 0.2, or 0.01 mg/day or placebo based on random assignment. Efficacy was determined by scalp hair counts, patient self-assessment, investigator assessment, and assessment of clinical photographs. Safety was assessed by clinical and laboratory measurements and by analysis of adverse experiences.
RESULTS:

Efficacy was demonstrated for all end points for finasteride at doses of 0.2 mg/day or higher, with 1 and 5 mg demonstrating similar efficacy that was superior to lower doses. Efficacy of the 0.01 mg dose was similar to placebo. No significant safety issues were identified in the trials.

CONCLUSION:

Finasteride 1 mg/day is the optimal dose for the treatment of men with male pattern hair loss and was subsequently identified for further clinical development.

[kurt]

Bonjour ,

Merci pour votre réponse.
Mais qu'en est-il du dosage 0.5 Mg au lieu de 1 mg ?
Une question encore : Qu'en est-il de l'avodart ?

Bien à vous,
Kurt.